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Research to Prevent Blindness

Research Archive

52 citations match:

2018 New Research

 

2017 New Research

A Comparison of En Face Optical Coherence Tomography and Fundus Autofluorescence in Stargardt Disease

Vivienne C. Greenstein, Jason Nunez, Winston Lee, Kaspar Schuerch, Brad Fortune, Stephen H. Tsang, Rando Allikmets, Janet R. Sparrow, Donald C. Hood
Invest. Ophthalmol. Vis. Sci. 2017;58(12):5227-5236

Intraretinal Correlates of Reticular Pseudodrusen Revealed by Autofluorescence and En Face OCT

Maarjaliis Paavo, Winston Lee, John Merriam, Srilaxmi Bearelly, Stephen Tsang, Stanley Chang, Janet R. Sparrow
Invest. Ophthalmol. Vis. Sci. 2017;58(11):4769-4777

Quantifying Fundus Autofluorescence in Patients with Retinitis Pigmentosa

Kaspar Schuerch, Russell L. Woods, Winston Lee, Tobias Duncker, François C. Delori, Rando Allikmets, Stephen H. Tsang, Janet R. Sparrow
Invest. Ophthalmol. Vis. Sci. 2017;58(3):1843-1855

 

2016 New Research

Simultaneous Expression of ABCA4 and GPR143Mutations: A Complex Phenotypic Manifestation

Winston Lee, Kaspar Schuerch, Yajing Xie, Jana Zernant, Stephen H. Tsang, Janet R. Sparrow, Rando Allikmets
Invest. Ophthalmol. Vis. Sci. 2016;57(7):3409-3415

 

2015 New Research

Quantitative Fundus Autofluorescence and Optical Coherence Tomography in ABCA4 Carriers

Tobias Duncker, Gregory E. Stein, Winston Lee, Stephen H. Tsang, Jana Zernant, Srilaxmi Bearelly, Donald C. Hood, Vivienne C. Greenstein, François C. Delori, Rando Allikmets, Janet R. Sparrow
Invest. Ophthalmol. Vis. Sci. 2015;56(12):7274-7285

Quantitative Fundus Autofluorescence and Optical Coherence Tomography in PRPH2/RDS- and ABCA4-Associated Disease Exhibiting Phenotypic Overlap

Tobias Duncker, Stephen H. Tsang, Russell L. Woods, Winston Lee, Jana Zernant, Rando Allikmets, François C. Delori, Janet R. Sparrow
Invest. Ophthalmol. Vis. Sci. 2015;56(5):3159-3170

Structural Modeling of a Novel CAPN5 Mutation that Causes Uveitis and Neovascular Retinal Detachment

Bassuk AG, Yeh S, Wu S, Martin DF, Tsang SH, et al.
PLoS ONE 10(4): e0122352

 

2014 New Research

Correlations Among Near-Infrared and Short-Wavelength Autofluorescence and Spectral-Domain Optical Coherence Tomography in Recessive Stargardt Disease.

Tobias Duncker, Marcela Marsiglia, Winston Lee, Jana Zernant, Stephen H. Tsang, Rando Allikmets, Vivienne C. Greenstein, Janet R. Sparrow.
Invest. Ophthalmol. Vis. Sci. 2014;55(12):8134-8143.

Structural and Genetic Assessment of the ABCA4-Associated Optical Gap Phenotype.

Kalev Nõupuu, Winston Lee, Jana Zernant, Stephen H. Tsang, Rando Allikmets.
Invest. Ophthalmol. Vis. Sci. 2014;55(11):7217-7226.

The external limiting membrane in early-onset stargardt disease.

Lee W, Nõupuu K, Oll M, Duncker T, Burke T, Zernant J, Bearelly S, Tsang SH, Sparrow JR, Allikmets R.
Investigative Ophthalmology & Visual Science 2014;55:6139-6149.

Choroidal and retinal thickening in severe preeclampsia.

Garg A, Wapner RJ, Ananth CV, Dale E, Tsang SH, Lee W, Allikmets R, Bearelly S.
Investigative Ophthalmology & Visual Science 2014;55:5723-5729.

Whole Exome Sequencing Identifies CRB1 Defect in an Unusual Maculopathy Phenotype

Tsang, Stephen H. et al.
Ophthalmology
September 2014 (Volume 121, Issue 9, 1773 – 1782)

Quantitative fundus autofluorescence in recessive stargardt disease.

Burke TR, Duncker T, Woods RL, Greenberg JP, Zernant J, Tsang SH, Smith RT, Allikmets R, Sparrow JR, Delori FC.
Investigative Ophthalmology & Visual Science 2014;55:2841-2852.

Whole Exome Sequencing Identifies CRB1 Defect in an Unusual Maculopathy Phenotype

Stephen H. Tsang, Tomas Burke, Maris Oll, Suzanne Yzer, Winston Lee, Yajing (Angela) Xie, Rando Allikmets
Ophthalmology - 08 May 2014 (10.1016/j.ophtha.2014.03.010)

Quantitative fundus autofluorescence and optical coherence tomography in best vitelliform macular dystrophy.

Duncker T, Greenberg JP, Ramachandran R, Hood DC, Smith RT, Hirose T, Woods RL, Tsang SH, Delori FC, Sparrow JR.
Investigative Ophthalmology & Visual Science 2014;55:1471-1482.

 

2013 New Research

Novel Compound Heterozygous Mutations Resulting in Cone Dystrophy With Supernormal Rod Response.

Lenis TL, Dhrami-Gavazi E, Lee W, Mukkamala SK, Tabacaru MR, Yannuzzi L, Gouras P, Tsang SH.
JAMA Ophthalmol. 2013;131(11):1482-1485.

Distinct characteristics of inferonasal fundus autofluorescence patterns in stargardt disease and retinitis pigmentosa.

Duncker T, Lee W, Tsang SH, Greenberg JP, Zernant J, Allikmets R, Sparrow JR.
Investigative Ophthalmology & Visual Science 2013;54:6820-6826.

Comparison of near-infrared and short-wavelength autofluorescence in retinitis pigmentosa.

Duncker T, Tabacaru MR, Lee W, Tsang SH, Sparrow JR, Greenstein VC.
Investigative Ophthalmology & Visual Science 2013;54:585-591.

 

2012 New Research

Retinal Phenotypes in Patients Homozygous for the G1961E Mutation in the ABCA4 Gene

Tomas R. Burke, Gerald A. Fishman, Jana Zernant, Carl Schubert, Stephen H. Tsang, R. Theodore Smith, Radha Ayyagari, Robert K. Koenekoop, Allison Umfress, Maria Laura Ciccarelli, Alfonso Baldi, Alessandro Iannaccone, Frans P. M. Cremers, Caroline C. W. Klaver, and Rando Allikmets
IOVS July 2012 53:4458-4467.

Infrared Imaging and Optical Coherence Tomography Reveal Early-Stage Astrocytic Hamartomas Not Detectable by Fundoscopy

Luna Xu, Tomas R. Burke, Jonathan P. Greenberg, Vinit B. Mahajan, Stephen H. Tsang
American Journal of Ophthalmology
May 2012 (Vol. 153, Issue 5, Pages 883-889.e2)

Progressive Constriction of the Hyperautofluorescent Ring in Retinitis Pigmentosa

Luiz H. Lima, Tomas Burke, Vivienne C. Greenstein, Chai Lin Chou, Wener Cella, Lawrence A. Yannuzzi, Stephen H. Tsang
American Journal of Ophthalmology
April 2012 (Vol. 153 issue 4 Pages 718-727.e2)

Infrared Imaging and Optical Coherence Tomography Reveal Early-Stage Astrocytic Hamartomas Not Detectable by Fundoscopy

Luna Xu, Tomas R. Burke, Jonathan P. Greenberg, Vinit B. Mahajan, Stephen H. Tsang
American Journal of Ophthalmology
February 2012 (10.1016/j.ajo.2011.10.033)

Autofluorescence Imaging and Spectral-Domain Optical Coherence Tomography in Incomplete Congenital Stationary Night Blindness and Comparison With Retinitis Pigmentosa

Royce W.S. Chen, Jonathan P. Greenberg, Margot A. Lazow, Rithu Ramachandran, Luiz H. Lima, John C. Hwang, Carl Schubert, Alexandra Braunstein, Rando Allikmets, Stephen H. Tsang
American Journal of Ophthalmology
January 2012 (Vol. 153, Issue 1, Pages 143-154.e2)

 

2011 New Research

Progressive Constriction of the Hyperautofluorescent Ring in Retinitis Pigmentosa

Luiz H. Lima, Tomas Burke, Vivienne C. Greenstein, Chai Lin Chou, Wener Cella, Lawrence A. Yannuzzi, Stephen H. Tsang
American Journal of Ophthalmology
December 2011 (10.1016/j.ajo.2011.08.043)

The Inner Segment/Outer Segment Border Seen on Optical Coherence Tomography Is Less Intense in Patients with Diminished Cone Function

Donald C. Hood, Xian Zhang, Rithambara Ramachandran, Christine L. Talamini, Ali Raza, Jonathan P. Greenberg, Jerome Sherman, Stephen H. Tsang, and David G. Birch
Invest. Ophthalmol. Vis. Sci. 2011 52:9703-9709.

Quantification of Peripapillary Sparing and Macular Involvement in Stargardt Disease (STGD1)

Tomas R. Burke, David W. Rhee, R. Theodore Smith, Stephen H. Tsang, Rando Allikmets, Stanley Chang, Margot A. Lazow, Donald C. Hood, and Vivienne C. Greenstein
Invest. Ophthalmol. Vis. Sci. 2011; 52:8006-8015.

Autofluorescence Imaging and Spectral-Domain Optical Coherence Tomography in Incomplete Congenital Stationary Night Blindness and Comparison with Retinitis Pigmentosa

Royce W.S. Chen, Jonathan P. Greenberg, Margot A. Lazow, Rithu Ramachandran, Luiz H. Lima, John C. Hwang, Carl Schubert, Alexandra Braunstein, Rando Allikmets, Stephen H. Tsang
American Journal of Ophthalmology
September 2011 (10.1016/j.ajo.2011.06.018)

 

2009 New Research

A Comparison of Fundus Autofluorescence and Retinal Structure in Patients with Stargardt Disease

Nuno L. Gomes, Vivienne C. Greenstein, Joshua N. Carlson, Stephen H. Tsang, R. Theodore Smith, Ronald E. Carr, Donald C. Hood, and Stanley Chang
Invest. Ophthalmol. Vis. Sci. 2009 50: 3953-3959.

Cellular and Molecular Origin of Circumpapillary Dysgenesis of the Pigment Epithelium

Joaquin Tosi, Kerstin M. Janisch, Nan-Kai Wang, J. Mie Kasanuki, John T. Flynn, Chyuan-Sheng Lin, Stephen H. Tsang
Ophthalmology
May 2009 (Vol. 116, Issue 5, Pages 971-980)

 

2008 New Research

A Novel Mutation and Phenotypes in Phosphodiesterase 6 Deficiency , 26 August 2008

Stephen H. Tsang, Irena Tsui, Chai Lin Chou, Jana Zernant, Eneli Haamer, Reza Iranmanesh, Joaquin Tosi, Rando Allikmets
American Journal of Ophthalmology
November 2008 (Vol. 146, Issue 5, Pages 780-788.e1)

Functional Rescue of Degenerating Photoreceptors in Mice Homozygous for a Hypomorphic cGMP Phosphodiesterase 6 b Allele (Pde6bH620Q)

Richard J. Davis, Joaquin Tosi, Kerstin M. Janisch, J. Mie Kasanuki, Nan-Kai Wang, Jian Kong, Ilene Tsui, Marianne Cilluffo, Michael L. Woodruff, Gordon L. Fain, Chyuan-Sheng Lin, and Stephen H. Tsang
Invest. Ophthalmol. Vis. Sci. 2008 49: 5067-5076.

 

2010 Research Archive

Rapid and noninvasive imaging of retinal ganglion cells in live mouse models of glaucoma

Tosi J, Wang NK, Zhao J, Chou CL, Kasanuki JM, Tsang SH, and Nagasaki T
Mol Imaging Biol 2010;12(4):386-393 (Columbia Univ. – Unres. Grant) Keyword(s): Retinal/Retinal Diseases

Loss of peripapillary sparing in non-group I stargardt disease

Burke TR, Allikmets R, Smith RT, Gouras P, Tsang SH
Exp Eye Res 2010;91(5):592-600 (Columbia Univ. – Unres. Grant) Keyword(s): Macular Dystrophy

 

2009 Research Archive

Structural Assessment of Hyperautofluorescent Ring in Patients with Retinitis Pigmentosa

Lima LH, Cella W, Greenstein VC, Wang NK, Busuioc M, Smith RT, Yannuzzi LA, Tsang SH
Retina 2009;29:1025-1031 (Columbia Univ. – Unres. Grant) Keyword(s): Retinitis Pigmentosa

A Comparison of Fundus Autofluorescence and Retinal Structure in Patients with Stargardt Disease

Gomes NL, Greenstein VC, Carlson JN, Tsang SH, Smith RT, Carr RE, Hood DC, Chang SC
Invest Ophthalmol Vis Sci 2009;50:3953-3959 (Columbia Univ. – Unres. Grant) Keyword(s): Retina/Retinal Diseases

G1961E mutant allele in the Stargardt disease gene ABCA4 causes bull’s eye maculopathy

Cella W, Greenstein VC, Zernant-Rajang J, Smith RT, Barile G, Allikmets R, Tsang SH
Exp Eye Res 2009;89:16-24 (Columbia Univ. – Unres. Grant) Keyword(s): Retina/Retinal Diseases

Autofluorescence Imaging and Phenotypic variance in a Sibling pair with Early Onset Retinal Dystrophy due to defective CRB1 function

Tosi J, Tsui I, Lima L, Wang NK, Tsang SH
Curr Eye Res 2009;34:395-400 (Columbia Univ. – Unres. Grant) Keyword(s): Gene Research/Therapy

Cellular origin of fundus autofluorescence in patients and mice with a defective NR2E3 gene

Wang NK, Fine HF, Chang S, Chou CL, Cella W, Tosi J, Lin CS, Nagasaki T, Tsang SH
Br J Ophthalmol 2009;93:1234-1240 (Columbia Univ. – Unres. Grant) Keyword(s): Genetics

Erythropoetin receptor expression in the human diabetic retina

Shah SS, Tsang SH, Mahajan VB
BMC Res Notes 2009;2:234 (Univ. of Iowa - Unres. Grant) Keyword(s): Diabetic Retinopathy

 

2008 Research Archive

Preferred retinal locus in macular disease: characteristics and clinical implications

Greenstein VC, Santos RAV, Tsang SH, Smith RT, Barile GR, Seiple W
Retina 2008;28:1234-1240 (Columbia Univ. – Unres. Grant) Keyword(s): AMD

Modulation of Phosphodiesterase6 Turnoff during Background Illumination in Mouse Rod Photoreceptors

Woodruff ML, Janisch KM, Peshenko IV, Dizhoor AM, Tsang SH, Fain GL
J Neuroscience 2008;28:2064-2074 (Columbia Univ. - Unres. Grant) Keyword(s): Retinitis Pigmentosa

Functional Rescue of Degenerating Photoreceptors in Mice Homozygous for a Hypomorphic cCMG Phosphodiesterase 6 b Allele (Pde6b H620Q)

Davis RJ, Tosi J, Janish KM, Kasanuki JM, Wang NK, Kong J, Tsui I, Cilluffo M, Woodruff ML, Fain GL, Lin CS, Tsang SH
Invest Ophthalmol Vis Sci 2008;49:5067-5076 (Columbia Univ. – Unres. Grant) Keyword(s): Retinitis Pigmentosa

Effects of extracellular matrix and neighboring cells on induction of human embryonic stem cells into retinal or retinal pigment epithelial progenitors

Gong J, Sagiv O, Cai H, Tsang SH, Del Priore LV
Exp Eye Res 2008;86:957-965 (Columbia Univ. – Unres. Grant) Keyword(s): AMD and Retinitis Pigmentosa

Non-vascular vision loss in pseudoxanthoma elasticum

Tsui I, Fuchs B, Chou CL, Chang S, Tsang SH
Doc Ophthalmol 2008;117:65-67 (Columbia Univ. – Unres. Grant) Keyword(s): Macular Dystrophy

Electronegative electroretinogram associated with topiramate toxicity and vitelliform maculopathy

Tsui I, Casper D, Chou CL, Tsang SH
Doc Ophthalmol 2008;116:57-60 (Columbia Univ. – Unres. Grant) Keyword(s): Macular Dystrophy

A novel mutation and phenotypes in phosphodiesterase 6 deficiency

Tsang SH, Tsui I, Chou CL, Zernant J, Haamer E, Iranmanesh R, Tosi J, Allikmets R
Am J Ophthalmol 2008;146:780-788 (Columbia Univ. – Unres. Grant) Keyword(s): Retinitis Pigmentosa

 

2007 Research Archive

Transducin translocation in rods is triggered by saturation of the GTPase activating complex

Lobanova ES, Finkelstein S, Song H, Tsang SH, Chen C-K, Sokolov M, Skiba NP, Arshavsky VY
J Neurosci 2007;27:1151–1160 (Duke Univ. – Unres. Grant and Sr. Scientific Inv. Awd): Keyword(s): Retinitis Pigmentosa

A practical approach to retinal dystrophies

Tsui I, Song B, Lin CS, Tsang S
Retinal Physician 2007;April:18-26 (Columbia Univ. – Unres. Grant) Keyword(s): Macular Dystrophy

Novel Phenotypic and Genotypic Findings in X-Linked Retinoschisis

Tsang SH, Vaclavik V, Bird AC, Robson AG, Holder GH
Arch Ophthalmol 2007;125:259-267 (Columbia Univ. – Unres. Grant) Keyword(s): Retinoschisis

 

2006 Research Archive

GAP-Independent Termination of Photoreceptor Light Response by Excess γ Subunit of the cGMP-Phosphodiesterase

Tsang SH, Woodruff ML, Chen CK, Yamashita CY, Cilluffo MC, Rao AL, Farber DB, Fain GL
J Neurosci 2006; 26:4472-4480 (Columbia Univ. – Unres. Grant) Keyword(s) Retinitis Pigmentosa

Transgenic Mice Carrying the H258N Mutation in the Gene Encoding the β-Subunit of Phosphodiesterase-6 (PDE6B) Provide a Model for Human Congenital Stationary Night Blindness

Tsang SH, Woodruff ML, Lin J, Mahajan V, Yamashita CK, Pedersen R, Lin CS, Goff SP, Rosenberg T, Larsen M, Farber DB and Nusinowitz S
Human Mutation 2006;0:1-12 (Columbia Univ. – Unres. Grant) Keyword(s): Retinitis Pigmentosa

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